Prediagnostic physical activity and colorectal cancer survival: Overall and stratified by tumor characteristics

S Hardikar; PA Newcomb; PT Campbell; AK Win; NM Lindor; DD Buchanan; KW Makar; MA Jenkins; JD Potter; AI Phipps

Journal article

Prediagnostic physical activity and colorectal cancer survival: Overall and stratified by tumor characteristics

S Hardikar, PA Newcomb, PT Campbell, AK Win, NM Lindor, DD Buchanan, KW Makar, MA Jenkins, JD Potter, AI Phipps

Cancer Epidemiology Biomarkers and Prevention | AMER ASSOC CANCER RESEARCH | Published : 2015

DOI: 10.1158/1055-9965.EPI-15-0039

Abstract

Background: Physical activity is associated with a lower incidence of colorectal cancer; however, the relationship of physical activity with colorectal cancer survival is not yet clear. We evaluated the association between prediagnostic physical activity and colorectal cancer survival, overall and accounting for tumor markers associated with colorectal cancer survival: BRAF and KRAS mutation status and microsatellite instability (MSI) status. Methods: Participants were 20- to 74-year-old colorectal cancer patients diagnosed between 1998 and 2007 from the populationbased Seattle Colon Cancer Family Registry (S-CCFR). Selfreported physical activity in the years preceding colorectal cancer diag..

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University of Melbourne Researchers

Aung Ko Win Author

Daniel Buchanan Author

Mark Jenkins Author

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Grants

Awarded by National Cancer Institute

Funding Acknowledgements

This work was supported by grant UM1CA167551 from the National Cancer Institute and through cooperative agreements with the following CCFR centers: Seattle Colorectal Cancer Family Registry (U01/U24 CA074794; to P.A. Newcomb and J.D. Potter), Australasian Colorectal Cancer Family Registry (U01 CA074778 and U01/U24 CA097735; to D.D. Buchanan, M.A. Jenkins), Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01/U24 CA074800; to N.M. Lindor), Ontario Familial Colorectal Cancer Registry (U01/U24 CA074783), University of Hawaii Colorectal Cancer Family Registry (U01/U24 CA074806), USC Consortium Colorectal Cancer Family Registry (U01/U24 CA074799). In addition, National Cancer Institute grants R25CA094880 (to S. Hardikar), R03CA165153 (to K.W. Makar), K05CA152715 (to P.A. Newcomb), and K07CA172298 (A.I. Phipps) have also supported this work. Paraffin-embedded tumor tissue for the Seattle Colorectal Cancer Family Registry was provided by The Jeremy Jass Memorial Pathology Bank.